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Oxymorphone is used to help relieve moderate to severe pain. It belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

Firstly, Oxymorphone, sold under the brand name Numorphan among others, is an opioid pain medication. Buy Opana ER 40mg (Oxymorphone) Online For Sale

Indications and Usage for Opana ER

Limitations of Use

• Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations [see Warnings and Precautions, reserve Opana ER for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

• Read the Medication Guide provided by your pharmacist before you start taking oxymorphone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
• Take this medication by mouth without food (at least 1 hour before or 2 hours after eating) as directed by your doctor, usually every 4 to 6 hours. If you have nausea, ask your doctor or pharmacist about ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).
• The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed because your risk of side effects may increase. Properly stop the medication when so directed.
• Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

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Dosage and Administration

2.1  Important Dosage and Administration Instructions

Opana ER should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.

• Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions.
• Initiate the dosing regimen for each patient individually, taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions.
• Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with Opana ER and adjust the dosage accordingly [see Warnings and Precautions.
• If you have ongoing pain (such as due to cancer), your doctor may direct you to also take long-acting opioid medications. In that case, this medication might be used for sudden (breakthrough) pain only as needed. Other pain relievers (such as acetaminophen, ibuprofen) may also be prescribed. Ask your doctor or pharmacist about using oxymorphone safely with other drugs.

Instruct patients to swallow Opana ER tablets whole, one tablet at a time, with enough water to ensure complete swallowing immediately after placing in the mouth [see Patient Counseling Information.  Crushing, chewing, or dissolving Opana ER tablets will result in uncontrolled delivery of oxymorphone and can lead to overdose or death [see Warnings and Precautions. Where to Buy Opana ER 40 mg (Oxymorphone) Online For Sale

Administer on an empty stomach, at least 1 hour prior to or 2 hours after eating.

Opana ER is administered orally every 12 hours.

2.2  Initial Dosing

Use of Opana ER as the First Opioid Analgesic

Initiate treatment with Opana ER with the 5 mg tablet orally every 12-hours.

Use of Opana ER in Patients who are not Opioid Tolerant

The starting dose for patients who are not opioid tolerant is Opana ER 5 mg orally every 12 hours.

Patients considered opioid tolerant are those taking, for one week or longer, at least 60 mg oral morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid.

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Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression.

Conversion from OPANA to Opana ER

Conversion from Parenteral Oxymorphone to Opana ER

In conclusion, the absolute oral bioavailability of Opana ER is approximately 10%. So, convert patients receiving parenteral oxymorphone to Opana ER by administering 10 times the patient’s total daily parental oxymorphone dose as Opana ER in two equally divided doses (e.g., [IV dose x 10] divided by 2).  Due to patient variability with regards to opioid analgesic response, upon conversion monitor patients closely to evaluate for adequate analgesia and side effects.